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Corning Life Sciences 10-layer cellstacks
10 Layer Cellstacks, supplied by Corning Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/10-layer+cellstacks/t+flasks/pmc12124627-181-104-106
Average 90 stars, based on 1 article reviews
10-layer cellstacks - by Bioz Stars, 2026-09
90/100 stars

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Recombinant:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Generated:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Homologous Recombination:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Plasmid Preparation:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Bioprocessing:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Expressing:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Functional Assay:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Produced:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Derivative Assay:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Stable Transfection:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.

Infection:

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al. Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences.
Article Snippet: Helper recombinant HSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap, under their respective endogenous promoters, as described in.21 Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
Article Snippet: Production of recombinant herpes viruses rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning) at an multiplicity of infection (MOI) of 0.15 pfu/cell.

Article Title: Characterization of factors that influence rAAV yield and quality when produced using rHSV co-infection
Article Snippet: Recombinant herpes viruses rHSV-RC and rHSV-GOI (rHSV-CK8-μDys5) were generated by homologous recombination on the backbone of d27-1 , a replication-defective HSV vector according to a previously published method., Although replication defective, d27.1 does express the HSV early genes required for AAV replication and packaging. rHSV-RC was engineered to express AAV2 rep and AAV9 cap genes and rHSV-GOI contains GOI, consisting of AAV2 ITRs and a muscle-specific CK8 promoter to drive expression of a fully functional truncated dystrophin termed micro-dystrophin (μDys5). rHSV stocks were produced by infecting complementing V27 cells, a line derived from parental Vero cells to stably expresses HSV ICP27 , using the 10-layer CellSTACKs (Corning Life Sciences) culture system using an MOI of 0.15 PFU/cell.

Article Title: Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions
Article Snippet: Suspension cultures, in which human mesenchymal stem cells are cultivated on microcarriers in scalable single-use stirred bioreactor types, have been shown to be a promising alternative to planar flask cultures.. However, stirred single-use bioreactors were originally developed for production processes with robust, permanent cell lines.. Human mesenchymal stem cells are adherent primary cells and thus expanding them in such bioreactor systems imposes more stringent requirements on bioreactor systems.

Article Title: AAV mediated influenza vaccines
Article Snippet: Cells are cultivated in Corning 10-layer CellSTACKs® (CS-10) and HYPERstack®36-layer (S-36) and all open manipulations are performed in class II biosafety cabinets in an ISO Class 5 environment.

Article Title: NaCl and KCl mediate log increase in AAV vector particles and infectious titers in a specific/timely manner with the HSV platform
Article Snippet: Helper rHSV-AAV9 contained the entire expression cassette of AAV2 Rep and AAV9 Cap under their respective endogenous promoters, as described in Adamson-Small et al.9 Production of rHSV-GFP and rHSV-AAV9 stocks was performed by infecting V27 cells in 10-layer CellSTACKs (Corning Life Sciences) at an MOI of 0.15 plaque-forming unit (PFU)/cell.

Article Title: Construction of stable packaging cell lines for clinical lentiviral vector production
Article Snippet: Vector production was also scaled up to allow the collection of 640 ml or 560 ml per harvest using 10-layer CellSTACKs (Corning) or HYPERFlasks (Corning) respectively.



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